Premium
Radiocopper for the imaging of copper metabolism
Author(s) -
Hueting Rebekka
Publication year - 2014
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3155
Subject(s) - copper , chemistry , metabolism , cofactor , copper metabolism , positron emission tomography , efflux , in vivo , biochemistry , enzyme , menkes disease , redox , homeostasis , inorganic chemistry , neuroscience , microbiology and biotechnology , biology , organic chemistry
The redox‐active transition metal copper is an essential trace element for growth and development and serves as a structural or catalytic cofactor for many enzymes in a range of physiological processes. Mammalian copper homeostasis is tightly regulated, and an imbalance in copper metabolism is implicated in various pathological disorders. Radioactive copper isotopes, in particular 64 Cu ( t 1/2 = 12.7 h) and 67 Cu ( t 1/2 = 62.01 h), have made important contributions to the understanding of copper metabolism in health and disease. This review gives a brief account of how radiolabelled copper(II) salts and bioreductive copper complexes have been used to trace copper uptake, transport and efflux in vitro and in vivo . Recently, positron emission tomography (PET) has emerged as a noninvasive tool to image copper metabolism in living subjects and 64 Cu‐PET is investigated for the study of copper‐related neurological disorders, genetic diseases and cancer. Copyright © 2014 John Wiley & Sons, Ltd.