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Imaging the inside of a tumour: a review of radionuclide imaging and theranostics targeting intracellular epitopes
Author(s) -
Cornelissen Bart
Publication year - 2014
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3152
Subject(s) - intracellular , extracellular , molecular imaging , epitope , radionuclide imaging , cell , angiogenesis , microbiology and biotechnology , chemistry , cancer research , computational biology , medicine , biology , immunology , nuclear medicine , biochemistry , in vivo , antibody
Molecular imaging of tumour tissue focusses mainly on extracellular epitopes such as tumour angiogenesis or signal transduction receptors expressed on the cell membrane. However, most biological processes that define tumour phenotype occur within the cell. In this mini‐review, an overview is given of the various techniques to interrogate intracellular events using molecular imaging with radiolabelled compounds. Additionally, similar targeting techniques can be employed for radionuclide therapy using Auger electron emitters, and recent advances in Auger electron therapy are discussed.