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Transition metal mediated [ 11 C]carbonylation reactions: recent advances and applications
Author(s) -
Kealey Steven,
Gee Antony,
Miller Philip W.
Publication year - 2014
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3150
Subject(s) - chemistry , carbonylation , synthon , carbon monoxide , labelling , rhodium , palladium , positron emission tomography , nanotechnology , combinatorial chemistry , catalysis , organic chemistry , biochemistry , medicine , materials science , radiology
[ 11 C]Carbon monoxide is undoubtedly a highly versatile radiolabelling synthon with many potential applications for the synthesis of positron emission tomography (PET) tracer molecules and functional groups, but why has it not found more applications in the PET radiolabelling arena? Today, 11 CO radiolabelling is still primarily viewed as a niche area; however, there are signs that this is beginning to change as some of the technical and chemistry challenges of producing, handling and reacting 11 CO are overcome. This mini review covers the more recent developments of 11 CO‐labelling chemistry and is focused on palladium and rhodium‐mediated carbonylation reactions that are growing in importance and finding wider application for carbon‐11 PET radiotracer development. Copyright © 2014 John Wiley & Sons, Ltd.