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High‐valent technetium chemistry—new opportunities for radiopharmaceutical developments
Author(s) -
Braband Henrik
Publication year - 2014
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3148
Subject(s) - chemistry , positron emission tomography , context (archaeology) , synthon , technetium , radiochemistry , technetium 99m , pet imaging , nanotechnology , nuclear medicine , nuclear chemistry , organic chemistry , medicine , materials science , scintigraphy , paleontology , biology
The rich coordination chemistry of 99m Tc distinguishes this radiometal from other radiolabels applied for single‐photon emission computed tomography (SPECT) or positron emission tomography (PET). This potential should be used to create novel opportunities for the development of effective imaging probes. In this context, the field of high‐valent technetium chemistry has received much interest. It has been shown that fac ‐{ 99m TcO 3 } + complexes are potential new synthons for radiopharmaceutical developments, due to their unique physicochemical properties and unprecedented reactivity. In this article, recent developments and the ‘state of the art’ in this field of technetium chemistry will be reviewed comprehensively. Copyright © 2013 John Wiley & Sons, Ltd.