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Synthesis of deuterium‐labeled cyamemazine and monodesmethyl cyamemazine
Author(s) -
Bolla R. Sekhar,
Kasi Viswanath I. V.
Publication year - 2014
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3145
Subject(s) - chemistry , desmethyl , derivative (finance) , deuterium , radiochemistry , phenothiazine , combinatorial chemistry , chemical synthesis , stereochemistry , in vitro , pharmacology , biochemistry , medicine , physics , quantum mechanics , metabolite , financial economics , economics
A novel approach is presented for the synthesis of cyamemazine maleate and N ‐desmethyl cyamemazine maleate using a 10‐(amino‐2‐methylpropyl)phenothiazine derivative. This method was successfully applied to the synthesis of [ 2 H 6 ]cyamemazine maleate and N ‐desmethyl‐[ 2 H 3 ]cyamemazine maleate. Copyright © 2013 John Wiley & Sons, Ltd.