Synthesis of deuterium‐labeled cyamemazine and monodesmethyl cyamemazine | Zendy

Bolla R. Sekhar | Zendy; Kasi Viswanath I. V. | Zendy

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Synthesis of deuterium‐labeled cyamemazine and monodesmethyl cyamemazine

Author(s) -

Bolla R. Sekhar,

Kasi Viswanath I. V.

Publication year - 2014

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.3145

Subject(s) - chemistry , desmethyl , derivative (finance) , deuterium , radiochemistry , phenothiazine , combinatorial chemistry , chemical synthesis , stereochemistry , in vitro , pharmacology , biochemistry , medicine , physics , quantum mechanics , metabolite , financial economics , economics

A novel approach is presented for the synthesis of cyamemazine maleate and N ‐desmethyl cyamemazine maleate using a 10‐(amino‐2‐methylpropyl)phenothiazine derivative. This method was successfully applied to the synthesis of [ 2 H 6 ]cyamemazine maleate and N ‐desmethyl‐[ 2 H 3 ]cyamemazine maleate. Copyright © 2013 John Wiley & Sons, Ltd.

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