One‐step radiosynthesis of 4‐nitrophenyl 2‐[ 18 F]fluoropropionate ([ 18 F]NFP); improved preparation of radiolabeled peptides for PET imaging | Zendy

Haskali Mohammad B. | Zendy; Roselt Peter D. | Zendy; Karas John A. | Zendy; Noonan Wayne | Zendy; Wichmann Christian W. | Zendy; Katsifis Andrew | Zendy; Hicks Rodney J. | Zendy; Hutton Craig A. | Zendy

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One‐step radiosynthesis of 4‐nitrophenyl 2‐[ 18 F]fluoropropionate ([ 18 F]NFP); improved preparation of radiolabeled peptides for PET imaging

Author(s) -

Haskali Mohammad B.,

Roselt Peter D.,

Karas John A.,

Noonan Wayne,

Wichmann Christian W.,

Katsifis Andrew,

Hicks Rodney J.,

Hutton Craig A.

Publication year - 2013

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.3111

Subject(s) - radiosynthesis , chemistry , yield (engineering) , pet imaging , radiochemistry , specific activity , fluoride , nuclear chemistry , enzyme , positron emission tomography , organic chemistry , nuclear medicine , inorganic chemistry , medicine , materials science , metallurgy

The versatile 18 F‐labeled prosthetic group, 4‐nitrophenyl 2‐[ 18 F]fluoropropionate ([ 18 F]NFP), was synthesized in a single step in 45 min from 4‐nitrophenyl 2‐bromopropionate, with a decay corrected radiochemical yield of 26.2% ± 2.2%. Employing this improved synthesis of [ 18 F]NFP, [ 18 F]GalactoRGD — the current ‘gold standard’ tracer for imaging the expression of α V β 3 integrin — was prepared with high specific activity in 90 min and 20% decay corrected radiochemical yield from [ 18 F]fluoride.

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