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One‐step radiosynthesis of 4‐nitrophenyl 2‐[ 18 F]fluoropropionate ([ 18 F]NFP); improved preparation of radiolabeled peptides for PET imaging
Author(s) -
Haskali Mohammad B.,
Roselt Peter D.,
Karas John A.,
Noonan Wayne,
Wichmann Christian W.,
Katsifis Andrew,
Hicks Rodney J.,
Hutton Craig A.
Publication year - 2013
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3111
Subject(s) - radiosynthesis , chemistry , yield (engineering) , pet imaging , radiochemistry , specific activity , fluoride , nuclear chemistry , enzyme , positron emission tomography , organic chemistry , nuclear medicine , inorganic chemistry , medicine , materials science , metallurgy
The versatile 18 F‐labeled prosthetic group, 4‐nitrophenyl 2‐[ 18 F]fluoropropionate ([ 18 F]NFP), was synthesized in a single step in 45 min from 4‐nitrophenyl 2‐bromopropionate, with a decay corrected radiochemical yield of 26.2% ± 2.2%. Employing this improved synthesis of [ 18 F]NFP, [ 18 F]GalactoRGD — the current ‘gold standard’ tracer for imaging the expression of α V β 3 integrin — was prepared with high specific activity in 90 min and 20% decay corrected radiochemical yield from [ 18 F]fluoride.