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Syntheses of 3 H‐labeled, 14 C‐labeled, and 2 H 4 ‐labeled SCH 444877, phosphodiesterase type 5 inhibitors
Author(s) -
Ren Sumei,
Hesk David,
McNamara Paul,
Koharski David,
Hendershot Sharon
Publication year - 2013
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3080
Subject(s) - chemistry , radiochemistry
The syntheses of [ 3 H]SCH 444877, [ 2 H 4 ]SCH 444877, and [ 14 C]SCH 444877 are described. [ 3 H]SCH 444877 was prepared in three steps from tritium gas. [ 2 H 4 ]SCH 444877 was synthesized from [ 2 H 4 ]ethanolamine in four steps with an overall yield of 40%. [ 14 C]SCH 444877 was prepared from barium [ 14 C]cyanamide in 10 steps with an overall yield of 8.1%.Copyright © 2013 John Wiley & Sons, Ltd.