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An efficient laboratory‐scale preparative method for [1‐ 13 C]glycocholic acid
Author(s) -
Mitome Hidemichi,
Tokumasu Naoko,
Tando Yusuke,
Nakamura Teruo,
Akira Kazuki
Publication year - 2013
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3072
Subject(s) - glycocholic acid , chemistry , substrate (aquarium) , yield (engineering) , chromatography , hydrochloride , biochemistry , bile acid , materials science , oceanography , cholic acid , metallurgy , geology
A breath test using [1‐ 13 C]glycocholic acid as a substrate is a potential diagnostic method for small intestinal bacterial overgrowth syndrome. [1‐ 13 C]Glycocholic acid has been thus synthesized in an excellent yield from ethyl [1‐ 13 C]glycinate hydrochloride in a one‐pot reaction. This method is suitable for the preparation of the labeled compound on a laboratory scale, which helps to perform extensive clinical studies of the breath test.