Pyridine derivatives, especially 2,6‐di‐ tert ‐butylpyridine, labeled with nitrogen‐15 | Zendy

Fărcaşiu Dan | Zendy; Lezcano Marta | Zendy

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Pyridine derivatives, especially 2,6‐di‐ tert ‐butylpyridine, labeled with nitrogen‐15

Author(s) -

Fărcaşiu Dan,

Lezcano Marta

Publication year - 2013

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.3071

Subject(s) - chemistry , pyridine , stoichiometry , acetic acid , catalysis , perchlorate , nitrogen , base (topology) , sodium acetate , sodium , nuclear chemistry , inorganic chemistry , medicinal chemistry , organic chemistry , ion , mathematical analysis , mathematics

Pyridine derivatives labeled with 15 N can be prepared by the reaction of the corresponding pyrylium salts with 15 NH 4 Cl in close to a stoichiometric ratio, in a sodium acetate–acetic acid buffer. In particular, the reaction of 2,6‐di‐ tert ‐butylpyrylium perchlorate gave 2,6‐di‐ tert ‐butylpyridine with a conversion of 95%. The compound is valuable for studies of acid–base interactions on solid acid catalysts by 15 N nuclear magnetic resonance.

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