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Pyridine derivatives, especially 2,6‐di‐ tert ‐butylpyridine, labeled with nitrogen‐15
Author(s) -
Fărcaşiu Dan,
Lezcano Marta
Publication year - 2013
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3071
Subject(s) - chemistry , pyridine , stoichiometry , acetic acid , catalysis , perchlorate , nitrogen , base (topology) , sodium acetate , sodium , nuclear chemistry , inorganic chemistry , medicinal chemistry , organic chemistry , ion , mathematical analysis , mathematics
Pyridine derivatives labeled with 15 N can be prepared by the reaction of the corresponding pyrylium salts with 15 NH 4 Cl in close to a stoichiometric ratio, in a sodium acetate–acetic acid buffer. In particular, the reaction of 2,6‐di‐ tert ‐butylpyrylium perchlorate gave 2,6‐di‐ tert ‐butylpyridine with a conversion of 95%. The compound is valuable for studies of acid–base interactions on solid acid catalysts by 15 N nuclear magnetic resonance.