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Straightforward preparation of labeled potassium cyanate by ozonation and application to the synthesis of [ 13 C] or [ 14 C]ureidocarboxylic acids
Author(s) -
Loreau Olivier,
Marlière Philippe
Publication year - 2013
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3041
Subject(s) - cyanate , chemistry , cyanide , potassium cyanide , yield (engineering) , reagent , potassium , combinatorial chemistry , organic chemistry , materials science , metallurgy
The development of new efficient syntheses of labeled reagents is a great challenge. Avoidance of overcomplicated procedures, availability and cost of starting materials are important considerations in choosing the synthetic route. In this report, we describe a facile and rapid preparation of labeled cyanate by ozonation of cyanide, a basic precursor. The crude cyanate was used without purification for the synthesis of various [ 13 C] or [ 14 C]ureidocarboxylic acids (20‐68% yield from potassium cyanide). According to these results, cyanide ozonation may prove to be a promising alternative to traditional preparations of labeled cyanate.