Premium
Synthesis of ximelagatran, melagatran, hydroxymelagatran, and ethylmelagatran in H‐3 labeled form
Author(s) -
Simonsson Roger,
Stenhagen Gunnar,
Ericsson Cecilia,
Elmore Charles S.
Publication year - 2013
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3028
Subject(s) - chemistry , tritium , catalysis , ximelagatran , radiochemistry , chemical synthesis , nuclear chemistry , combinatorial chemistry , organic chemistry , biochemistry , in vitro , medicine , physics , dabigatran , nuclear physics , warfarin , atrial fibrillation , cardiology
In support of a study designed to better understand the liver toxicity of ximelagatran, ximelagatran, and melagatran, hydroxymelagatran and ethylmelagatran were prepared in tritium labeled form. Incorporation of tritium was achieved by hydrogen isotope exchange using Crabtree's catalyst and later with N ‐heterocyclic containing Ir catalyst. The tritiated product was then converted into the four target compounds to afford them in high purity and specific activity.