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Synthetic strategies for radioligands for in vivo imaging of brain cannabinoid type‐1 receptors
Author(s) -
Ahamed Muneer,
Verbruggen Alfons,
Bormans Guy
Publication year - 2013
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3017
Subject(s) - cannabinoid receptor , in vivo , cannabinoid , neuroscience , receptor , chemistry , preclinical imaging , pharmacology , psychology , biochemistry , biology , antagonist , microbiology and biotechnology
Despite its abundant expression in the brain, the cannabinoid type‐1 (CB1) receptor was discovered only in 1988. During the last decade, efforts from several research groups have made it possible to visualize the CB1 receptor in vivo to unravel its role in the brain physiology and pathology. This review discusses strategies for (radio)synthesis of radioligands for in vivo imaging of CB1 receptors.