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Preparation of [ 3 H]fluoroethyl tosylate and its use in the labelling of the dopamine transporter radioligand [ 3 H]FE‐PE2I
Author(s) -
Cochrane Alison R,
Kerr William John,
Sandell Johan
Publication year - 2013
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3012
Subject(s) - chemistry , labelling , tritium , radioligand , radiochemistry , dopamine transporter , dopamine , nuclear chemistry , transporter , receptor , biochemistry , nuclear physics , gene , neuroscience , biology , physics
[ 3 H]Fluoroethyl tosylate, a novel alkylating tritium labelling agent, was synthesized from tritium gas with high specific activity and with 99% radiochemical purity. [ 3 H]Fluoroethyl tosylate was applied in the tritium labelling of the dopamine transporter radioligand [ 3 H]FE‐PE2I. Copyright © 2012 John Wiley & Sons, Ltd.