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PET radioligands targeting the brain GABA A /benzodiazepine receptor complex
Author(s) -
Andersson Jan D.,
Halldin Christer
Publication year - 2013
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3008
Subject(s) - chemistry , gabaa receptor , benzodiazepine , receptor , positron emission tomography , pharmacology , neuroscience , stereochemistry , biochemistry , psychology , medicine
The development of positron emission tomography radioligands for the GABA A /benzodiazepine receptor complex (GABA A receptor) labeled with 11 C and 18 F is examined. The review covers labeling strategies as well as brief biological evaluations of radioligands. In addition, we assess the special considerations that must be taken during a development program for radioligands targeting the GABA A receptor and explore some of the challenges that lie ahead. Copyright © 2013 John Wiley & Sons, Ltd.