PET radioligands targeting the brain GABA A /benzodiazepine receptor complex | Zendy

Andersson Jan D. | Zendy; Halldin Christer | Zendy

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PET radioligands targeting the brain GABA A /benzodiazepine receptor complex

Author(s) -

Andersson Jan D.,

Halldin Christer

Publication year - 2013

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.3008

Subject(s) - chemistry , gabaa receptor , benzodiazepine , receptor , positron emission tomography , pharmacology , neuroscience , stereochemistry , biochemistry , psychology , medicine

The development of positron emission tomography radioligands for the GABA A /benzodiazepine receptor complex (GABA A receptor) labeled with 11 C and 18 F is examined. The review covers labeling strategies as well as brief biological evaluations of radioligands. In addition, we assess the special considerations that must be taken during a development program for radioligands targeting the GABA A receptor and explore some of the challenges that lie ahead. Copyright © 2013 John Wiley & Sons, Ltd.

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