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Radioligands for the dopamine receptor subtypes
Author(s) -
Prante Olaf,
Maschauer Simone,
Banerjee Ashutosh
Publication year - 2013
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.3000
Subject(s) - dopamine , dopamine receptor , chemistry , postsynaptic potential , receptor , neurotransmitter , dopamine receptor d2 , positron emission tomography , neuroscience , dopamine receptor d1 , neurotransmitter receptor , pharmacology , in vivo , dopamine receptor d3 , biochemistry , psychology , medicine , biology , microbiology and biotechnology
The actions of the predominant neurotransmitter in the brain, dopamine, are mediated by the postsynaptic dopamine receptors. The five dopamine receptor subtypes and their regulation have been associated with a large variety of psychiatric diseases. Therefore, positron emission tomography (PET) imaging studies using suitable and selective 18 F‐labeled and 11 C‐labeled dopamine receptor radioligands could provide valuable knowledge on the impact of receptor density on the pathogenesis and evolvement of neuropsychiatric and neurological diseases. This special issue subchapter provides a summary of the most important 18 F‐labeled and 11 C‐labeled radioligands for PET imaging of the dopamine receptor subtypes, their radiochemistry, and characteristics from in vitro and in vivo applications, considering not only the already established PET ligands but also the recently published preclinical work. Copyright © 2013 John Wiley & Sons, Ltd.