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Positron emission tomography radiotracers for imaging hypoxia
Author(s) -
Wuest Melinda,
Wuest Frank
Publication year - 2013
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2997
Subject(s) - positron emission tomography , hypoxia (environmental) , chemistry , pet imaging , molecular imaging , nuclear medicine , preclinical imaging , medical physics , medicine , in vivo , oxygen , microbiology and biotechnology , organic chemistry , biology
Localized hypoxia, the physiological hallmark of many clinical pathologies, is the consequence of acute or chronic ischemia in the affected region or tissue. The versatility, sensitivity, quantitative nature, and increasing availability of positron emission tomography (PET) make it the preclinical and clinical method of choice for functional imaging of tissue hypoxia at the molecular level. The progress and current status of radiotracers for hypoxia‐specific PET imaging are reviewed in this article including references mainly focused on radiochemistry and also relevant to molecular imaging of hypoxia in preclinical and clinical studies.