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Methods for 11 C‐ and 18 F‐labelling of amino acids and derivatives for positron emission tomography imaging
Author(s) -
Ermert Johannes,
Coenen Heinz H.
Publication year - 2013
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2996
Subject(s) - chemistry , amino acid , radiosynthesis , labelling , radiochemistry , positron emission tomography , positron , nuclear medicine , nuclear physics , biochemistry , physics , medicine , electron
The different concepts realized for the synthesis of 11 C‐ and 18 F‐labelled amino acids are summarized. Carbon‐11 enables principally authentic radiolabelling of natural occurring amino acids by substituting one of the skeleton carbons by the radionuclide. Fluorine‐18 is a foreign element for natural amino acids. Because of its advantageous nuclidic properties for positron emission tomography, however, it becomes increasingly important in molecular imaging, also with amino acid analogues. Especially in the last decade, considerable progress has been made with the radiosynthesis of 18 F‐labelled amino acids that are now clinically approved, and thus assure their availability. In contrast, the synthetic possibilities with 11 C‐labelled amino acids are more limited because of the short half‐life of carbon‐11 which also hampers their wide spread use. Copyright © 2013 John Wiley & Sons, Ltd.