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Preliminary studies of a novel cyclopentadienyl tricarbonyl technetium‐99m fatty acid derivative for myocardical imaging
Author(s) -
Zeng Huahui,
Zhang Huabei,
Wu Xiangxiang,
Chao Fangfang,
Yu Gang,
Zhang Liqing,
Jiang Han,
Liu Hongbiao,
Hou Haifeng,
Zhan Hongwei,
Zhang Hong,
Tian Mei
Publication year - 2013
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2987
Subject(s) - biodistribution , chemistry , technetium 99m , technetium , cyclopentadienyl complex , fatty acid , radiochemistry , myocardial imaging , yield (engineering) , derivative (finance) , nuclear medicine , scintigraphy , organic chemistry , biochemistry , nuclear chemistry , catalysis , in vitro , medicine , materials science , economics , financial economics , metallurgy
This study reports the synthesis and evaluation studies of 6′‐cyclopentadienyl tricarbonyl technetium‐99m 6′‐oxo‐11‐(hexanamide)undecanoic acid (1). 1 was prepared with 26.5 ± 4.3% of radiochemical yield and more than 98% of radiochemical purity. Tissue distribution in mice showed that high radioactivity accumulated in the heart with moderate clearance. However, unfortunately, similar to those of other technetium‐labeled fatty acid analogs, the biodistribution studies of 1 in mice showed poor heart‐to‐blood ratios, which suggested that 1 cannot be used as myocardial imaging agent, and it may provide a theoretical basis or a lab experience for corresponding fatty acid tracers studies.