Synthesis of acyl[ 35 S]sulfonamides: Coupling of high specific activity [ 35 S]methane sulfonamide with acids and acid chlorides

Direct coupling of high specific activity [ 35 S]methanesulfonamide, generated from [ 35 S]methanesulfonyl chloride and ammonia, with acids and acid chlorides afforded the corresponding [ 35 S]acyl sulfonamides in excellent yields. Examples of high specific activity [ 35 S]acyl sulfonamides were prepared containing functionality that can be further elaborated through carbon–carbon or carbon–nitrogen bond forming reactions.