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Synthesis of acyl[ 35 S]sulfonamides: Coupling of high specific activity [ 35 S]methane sulfonamide with acids and acid chlorides
Author(s) -
Wallace Michael,
Allentoff Alban J.,
Bonacorsi Samuel
Publication year - 2012
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2974
Subject(s) - chemistry , sulfonamide , ammonia , carbon fibers , organic chemistry , chloride , nitrogen , methane , carbon chain , acyl chloride , carbon 13 , medicinal chemistry , materials science , composite number , composite material , physics , quantum mechanics
Direct coupling of high specific activity [ 35 S]methanesulfonamide, generated from [ 35 S]methanesulfonyl chloride and ammonia, with acids and acid chlorides afforded the corresponding [ 35 S]acyl sulfonamides in excellent yields. Examples of high specific activity [ 35 S]acyl sulfonamides were prepared containing functionality that can be further elaborated through carbon–carbon or carbon–nitrogen bond forming reactions.