An innovative and efficient synthesis of stable isotope labelled 1‐methyl‐5‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)‐1H‐pyrazole via [ 13 C 4  2 H 3 ]  N ‐methylpyrazole | Zendy

Manning Calvin | Zendy; Athlan Audrey | Zendy; Badman Geoff | Zendy

Premium

An innovative and efficient synthesis of stable isotope labelled 1‐methyl‐5‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)‐1H‐pyrazole via [ 13 C 4 2 H 3 ] N ‐methylpyrazole

Author(s) -

Manning Calvin,

Athlan Audrey,

Badman Geoff

Publication year - 2012

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.2971

Subject(s) - chemistry , malonate , diethyl malonate , pyrazole , stable isotope ratio , isotope , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , catalysis , physics , quantum mechanics

In support of a programme to develop a treatment for cancer, a stable isotope labelled version of the drug candidate was required. The key labelled intermediate was [ 13 C 4 2 H 3 ] N ‐methylpyrazole prepared by a novel bisacetal cyclisation. This was prepared from commercially available diethyl [ 13 C 3 ] malonate and [ 13 C 2 H 3 ] iodomethane. Copyright © 2012 John Wiley & Sons, Ltd.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research