[ 18 F]Fluoride labelling of macromolecules in aqueous conditions: silicon and boroaryl‐based [ 18 F]fluorine acceptors, [ 18 F]FDG conjugation and Al 18 F chelation | Zendy

Smith Tim A. D. | Zendy

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[ 18 F]Fluoride labelling of macromolecules in aqueous conditions: silicon and boroaryl‐based [ 18 F]fluorine acceptors, [ 18 F]FDG conjugation and Al 18 F chelation

Author(s) -

Smith Tim A. D.

Publication year - 2012

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.2940

Subject(s) - chemistry , fluorine , macromolecule , fluoride , aqueous solution , labelling , boron , molecule , acceptor , silicon , nucleophilic substitution , nucleophile , radiochemistry , inorganic chemistry , medicinal chemistry , organic chemistry , catalysis , biochemistry , physics , condensed matter physics

[ 18 F]Fluorination is usually carried out by nucleophilic substitution reactions entailing the use of stringent conditions. A number of novel techniques including silicon and boron‐based fluoride acceptor molecules, [ 18 F]fluoro‐2‐deoxy‐ d ‐glucose and chelation of the Al 18 F complex have been employed recently to achieve [ 18 F]radiolabelling of macromolecules. These approaches are reviewed herein. Copyright © 2012 John Wiley & Sons, Ltd.

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