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[ 18 F]Fluoride labelling of macromolecules in aqueous conditions: silicon and boroaryl‐based [ 18 F]fluorine acceptors, [ 18 F]FDG conjugation and Al 18 F chelation
Author(s) -
Smith Tim A. D.
Publication year - 2012
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2940
Subject(s) - chemistry , fluorine , macromolecule , fluoride , aqueous solution , labelling , boron , molecule , acceptor , silicon , nucleophilic substitution , nucleophile , radiochemistry , inorganic chemistry , medicinal chemistry , organic chemistry , catalysis , biochemistry , physics , condensed matter physics
[ 18 F]Fluorination is usually carried out by nucleophilic substitution reactions entailing the use of stringent conditions. A number of novel techniques including silicon and boron‐based fluoride acceptor molecules, [ 18 F]fluoro‐2‐deoxy‐ d ‐glucose and chelation of the Al 18 F complex have been employed recently to achieve [ 18 F]radiolabelling of macromolecules. These approaches are reviewed herein. Copyright © 2012 John Wiley & Sons, Ltd.