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A practical radiosynthesis of a tritium‐labelled fluorocombretastatin
Author(s) -
Hadfield John A.,
Hirst Nicholas,
Gaukroger Keira,
Lawrence Nicholas J.,
McGown Alan T.
Publication year - 2012
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2939
Subject(s) - radiosynthesis , chemistry , tritium , radiochemistry , combinatorial chemistry , chemical synthesis , in vitro , biochemistry , nuclear medicine , positron emission tomography , medicine , physics , nuclear physics
Zybrestat (combretastatin A‐4 disodium diphosphate) is currently in clinical trials as an antivascular anticancer agent. A similar fluorinated agent has shown promise as an antivascular agent, and a radiolabelled version would enable further understanding of its biological activities. Herein is described the synthesis of a tritiated fluorinated analogue of Zybrestat. Copyright © 2012 John Wiley & Sons, Ltd.