Synthesis of a  35 S‐labeled dinucleoside phosphorothioate prodrug, an orally bioavailable anti‐HBV agent | Zendy

Rhee SungWhi | Zendy; Iyer Radhakrishnan P. | Zendy; Coughlin John E. | Zendy; Padmanabhan Seetharamaiyer | Zendy; Malerich Jeremiah P. | Zendy; Tanga Mary J. | Zendy

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Synthesis of a 35 S‐labeled dinucleoside phosphorothioate prodrug, an orally bioavailable anti‐HBV agent

Author(s) -

Rhee SungWhi,

Iyer Radhakrishnan P.,

Coughlin John E.,

Padmanabhan Seetharamaiyer,

Malerich Jeremiah P.,

Tanga Mary J.

Publication year - 2012

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.2925

Subject(s) - chemistry , prodrug , bioavailability , reagent , radiochemistry , combinatorial chemistry , nuclear chemistry , pharmacology , organic chemistry , biochemistry , medicine

The 35 S‐labeled, dinucleoside phosphorothioate 1, an orally available agent against hepatitis B virus, was prepared in eight steps with high specific activity and radiochemical purity. Radiolabeled 3 H ‐benzodithiole‐3‐one‐1,1‐dioxide was synthesized in four steps from 35 S 8 and was used as the sulfurizing reagent. Copyright © 2012 John Wiley & Sons, Ltd.

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