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Synthesis of betamethasone‐l,2‐ 3 h 2 17‐benzoate
Author(s) -
Kobari T.,
Watanabe S.,
Ikegami S.
Publication year - 1975
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590110415
Subject(s) - dehydrogenation , yield (engineering) , chemistry , tris , triphenylphosphine , chloride , betamethasone , medicinal chemistry , catalysis , nuclear chemistry , organic chemistry , materials science , medicine , biochemistry , metallurgy , immunology
Abstract A new convenient method for the preparation of the title compound is described. The method consists of selective tritiation of betamethasone 17‐benzoate (9α‐fluoro‐11β,17,21‐trihydroxy‐16β‐methyl‐1,4‐pregnadiene‐3,20‐dione 17‐benzoate) (1) with the use of tris(triphenylphosphine)rhodium chloride as catalyst, followed by dehydrogenation with 2,3‐dichloro‐5,6‐dicyano‐1,4‐benzoquinone (DDQ). A favorable overall radiochemical yield is obtained.