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Synthesis of some 14 C‐labelled isoxazole derivatives
Author(s) -
Minato H.,
Nagasaki T.,
Katsuyama Y.
Publication year - 1975
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590110213
Subject(s) - isoxazole , yield (engineering) , chemistry , acetone , ring (chemistry) , urea , medicinal chemistry , carbon fibers , organic chemistry , mathematics , materials science , metallurgy , algorithm , composite number
Isoxazole derivatives, 3‐sulfanilamido‐5‐methylisoxazole (I) and 3,3‐dimethyl‐1‐(5‐methyl‐3‐isoxazolylcarbonyl)‐urea (II), have been labelled with carbon‐14. The carbon‐14 label was incorporated into the C‐5 of the isoxazole ring to give (I) and (II) in 22.3% and 33.0% radiochemical yield based on acetone‐ 14 C, respectively.