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Synthesis of 3,3‐( 14 C)‐dimethyl‐1‐phenyltriazene from 14 C‐dimethylamine hydrochloride and benzene‐diazonium fluoroborate
Author(s) -
Kolar G. F.,
Schweickhardt Ch.
Publication year - 1975
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590110106
Subject(s) - dimethylamine , chemistry , hydrochloride , nuclear chemistry , benzene , aqueous solution , ether , yield (engineering) , organic chemistry , materials science , metallurgy
3,3‐( 14 C)‐Dimethyl‐1‐phenyltriazene was prepared from recrystallized benzenediazonium fluoroborate which was coupled with 14 C‐dimethylamine in excess aqueous sodium carbonate at 0°. The crude product was extracted with ether and purified by distillation. Redistilled 14 C‐labelled triazene was obtained in good yield (70.4 and 73.5%) and in high radiochemical purity (better than 99.9% by scan of thin‐layer chromatograms). The specific activities of two preparations, determined by liquid scintillation counting and corrected for quenching, were 244 and 296 μCi/mmole. The determined activities were in close agreement with values computed from the specific activity of 14 C‐dimethylamine hydrochloride used in the synthesis.