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Synthesis of 14 C‐labelled 3‐(1‐hydroxy‐2‐piperidinoethyl)‐5‐phenylisoxazole citrate (31252‐S)
Author(s) -
Minato H.,
Nagasaki T.,
Yokoshima T.,
Suga K.,
Yamaguchi M.
Publication year - 1974
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590100414
Subject(s) - yield (engineering) , chemistry , isoxazole , ring (chemistry) , carbon 14 , carbon fibers , molecule , carbon chain , methyl iodide , medicinal chemistry , iodide , stereochemistry , radiochemistry , organic chemistry , mathematics , materials science , physics , algorithm , quantum mechanics , composite number , metallurgy
3‐(1‐Hydroxy‐2‐piperidinoethyl)‐5‐phenylisoxazole citrate, 31252‐S (I) has been labelled with carbon‐14. The carbon‐14 label was incorporated into the C‐2 position of the side‐chain to give (II) and into the C‐4 position of the isoxazole ring of the molecule to give (III). The carbon‐14 labelled products (II) and (III) were obtained in 27% and 6.4% ratiochemical yield based on methyl iodide‐ 14 C, respectively.