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Synthesis of 5α‐pregnane‐3β,20α‐diol and of 5α‐pregnane‐3α,20α‐diol labelled specifically at the 20β‐position
Author(s) -
Baillie T. A.,
Herz J. E.,
Sjövall J.
Publication year - 1974
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590100405
Subject(s) - pregnane , diol , chemistry , chromatography , stereochemistry , organic chemistry
A convenient synthesis of 5α‐[20β‐ 2 H]pregnane‐3α,20α‐diol and 5α‐[20β‐ 2 H]pregnane‐3β,20α‐diol from 3β‐hydroxy‐5α‐pregn‐16‐en‐20‐one is described. The reaction products are characterized by combined gas chromatography‐mass spectrometry.