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Steroids XLI. preparation of 9α, 11ζ‐tritiated estrone‐3‐methyl ether and following syntheses of 17α‐CH 2 X‐derivatives of estradiol
Author(s) -
Ponsold K.,
Römer J.,
Wagner H.
Publication year - 1974
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590100403
Subject(s) - estrone , chemistry , ether , radiolysis , organic chemistry , tritiated water , radiochemistry , tritium , biochemistry , hormone , aqueous solution , physics , nuclear physics
The preparation of 9α, 11ζ‐tritiated estrone‐3‐methyl ether with high specific activity is described. The following syntheses gave 17α‐CH 2 X‐derivatives of estradiol (X = CN and SCN) with high specific activity and radiochemical purity higher than 98%. Radiolysis and storage conditions are examined.
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