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Synthesis of carbon‐ 14 labeled diphenylhydantoin and its major metabolite 5‐(p‐hydroxyphenyl)‐5‐phenylhydantoin (HPPH) in 70 minutes
Author(s) -
Stavchansky S.,
Kostenbauder H. B.
Publication year - 1974
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590100314
Subject(s) - metabolite , chemistry , in vivo , carbon 14 , isotope , radiochemistry , isotopes of carbon , molecule , carbon fibers , organic chemistry , biochemistry , materials science , physics , total organic carbon , biology , microbiology and biotechnology , quantum mechanics , composite number , composite material
Abstract A simple and convenient method for the synthesis of carbon‐ 14 labeled diphenylhydantoin (DPH) (I) and its major metabolite 5‐(p‐hydroxyphenyl)‐5‐phenylhydantoin (HPPH) (II) in 70 minutes is described. This synthesis allows incorporation of carbon‐11‐ 11 (physical half‐life 20 minutes) into these molecules. Incorporation of short‐lived isotopes into drug molecules provides a vastly expanded potential for study of in vivo distribution of drugs and development of tumor specific agents.