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Preparation of fluothane‐ 82 Br by means of recoil labeling
Author(s) -
Hoizumi Kiyoshi,
Mogi Terutomi,
Kudo Hiroshi
Publication year - 1974
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590100311
Subject(s) - radiochemistry , recoil , chemistry , irradiation , neutron , bromine , yield (engineering) , nuclear chemistry , chromatography , materials science , nuclear physics , organic chemistry , physics , metallurgy
Fluothane (1, 1, 1‐trifluoro‐2‐chloro‐2‐bromoethane) is a well known anesthetic, and its labeled compound has been much required for the biological investigation. The method was studied to prepare fluochane‐ 82 Br by means of recoil labeling. More than 20 organic species labeled with bromine‐82 evolved in neutron‐irradiated fluothane. From such the complicated system, however, fluothane‐ 82 Br was purely obtained by the gas chromatographic separation. Under the optimum conditions, the radiochemical yield of fluothane‐ 82 Br contributed to 38%. When 200 μl of the target material was irradiated with neutrons to the total neutron dose (nvt) of 3.4 × 10 16 n/cm 2 , the radioactivity of 82 Br‐labeled fluothane isolated almost quantitatively was about 2.7 mCi.