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Synthesis of 6‐/N,N‐1′,6′‐hexyleneformamidine‐ 14 C/‐penicillanic acid
Author(s) -
Zupanska Janina,
Szymoniak Krystina,
BuskoOszczapowicz Irena,
Cieslak Jerzy
Publication year - 1974
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590100310
Subject(s) - oxalyl chloride , chemistry , formic acid , trimethylsilyl , yield (engineering) , chloride , medicinal chemistry , nuclear chemistry , stereochemistry , organic chemistry , materials science , metallurgy
Synthesis of 6‐/N,N‐1′, 6′‐hexyleneformamidine‐ 14 C/penicillanic acid /VII/ was carried out. N‐formyl‐ 14 C‐hexamethyleneimine /II/ was obtained from formic‐14C acid and hexamethyleneimine /I/. The product was chlorinated with oxalyl chloride. The obtained N,N‐1, 6‐hexylenechloroformimino‐ 14 C chloride /III/ was condensed with trimethylsilyl ester of N‐trimethylsilyl‐6‐amino penicillanic acid /V/. The final product /VII/ was separated with a radiochemical yield of 46.5%.