Premium
Synthesis of carbon‐14 labeled 1,4‐benzodiazepnies. II. (1) diazepam‐ 14 C , demethyldiazepam‐ 14 C, and ketazolam‐ 14 C
Author(s) -
Hsi Richard S. P.
Publication year - 1974
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590100304
Subject(s) - diazepam , diketene , glycine , chemistry , chromatography , organic chemistry , anesthesia , amino acid , biochemistry , medicine
Diazepam‐ 14 C and demethyldiazepam‐ 14 C are synthesized from glycine‐1‐ 14 C. Addition of diketene to diazepam‐ 14 C leads to ketazolam‐ 14 C. The reaction conditions for the formation of ketazolam from diazepam is studied using high‐pressure liquid chromatography in conjunction with radioactivity determinations.