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The synthesis of 14 C‐labelled (U) 2,4,2′,4′‐tetrachlorobiphenyl
Author(s) -
Melvas B.
Publication year - 1974
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590100217
Subject(s) - thionyl chloride , yield (engineering) , chlorine , ampoule , chemistry , benzene , condensation , nuclear chemistry , nitro , organic chemistry , chloride , radiochemistry , medicinal chemistry , materials science , metallurgy , physics , alkyl , thermodynamics
It was possible to prepare 14 C‐2,4,2′,4′‐tetrachlorobiphenyl with a purity of 98% by condensation of 14 C‐1‐chloro‐2,4‐dinitro‐benzene to yield 14 C‐2,4,2′,4′,‐tetranitrobiphenyl and substitution of the nitro groups by chlorine with thionyl chloride. The synthesis must be carried out on a small scale for two reasons‐the cost and the hazards with radioactive material. The synthesis described here was performed on a 10mg scale. Both of the chemical reactions were performed in sealed ampoules and the overall yield varied between 30 and 40%.