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Production of 1‐ 11 C‐acetoacetic acid
Author(s) -
Straatman Maria G.,
Hortmann Alfred G.,
Welch Michael J.
Publication year - 1974
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590100121
Subject(s) - acetone , yield (engineering) , acetoacetic ester synthesis , chemistry , in vivo , organic chemistry , biology , materials science , microbiology and biotechnology , metallurgy
Interest in labeled compounds which can be studied as brain metabolites and can be detected in vivo has led to production of carbon‐11 labeled acetoacetic acid (1‐ 11 C‐acetoacetic acid). This synthesis, which was designed specifically for use with short‐lived isotopes, utilizes a solution of the stable enolate anion of acetone, generated by the reaction of CH 3 Li and isopropenyl acetate, to which the 11 CO 2 is added to produce the labeled acetoacetic acid in ∼55% yield with a synthesis time of only 40 minutes from the end of bombardment.