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Synthesis of 8‐chloro‐6‐phenyl‐4H‐s‐triazolo [4,3‐a] [1,4] benzo‐diazepine‐1‐ 14 C
Author(s) -
Hayashi Nobuyoshi,
Shinozaki Kazuo,
Kato Shinji,
Meguro Kanji,
Kuwada Yutaka
Publication year - 1974
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590100109
Subject(s) - chemistry , formic acid , diazepine , yield (engineering) , benzodiazepine , medicinal chemistry , d 1 , organic chemistry , stereochemistry , ring (chemistry) , biochemistry , materials science , receptor , metallurgy
8‐Chloro‐6‐phenyl‐4H‐s‐triazolo [4,3‐a] [1,4] benzodiazepine (D‐40TA)‐1‐ 14 C (V‐ 14 C) was synthesized by the reaction of formic acid‐ 14 C with 7‐chloro‐2‐hydrazino‐5‐phenyl‐3H‐1, 4‐benzodiazepine in the presence of N,N′‐carbonylbis (2‐methylimidazole). The overall radio‐chemical yield from formic acid‐ 14 C was 57.8%.
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