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Syntheses of 2(IH)‐quinazolinone‐4‐ 14 C derivatives
Author(s) -
Yoshitake A.,
Makari Y.,
Endo M.
Publication year - 1973
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590090318
Subject(s) - quinazolinone , chemistry , carbon dioxide , nitro , medicinal chemistry , radiochemistry , stereochemistry , organic chemistry , alkyl
L‐Cyelopropy lmethyl‐6‐methoxy‐4‐phenyl‐2 (1H)‐qiomazpmpme (III) (SL‐573) and l‐Cyclopropylmethyl‐6‐nitro‐4‐phenyl‐2( 1H )‐quinazolinone (VI) (SL‐522), each labelled with carbon ‐14 at C‐4 position were synthesized for use in metabolic studies. The syntheses were achieved by two types of reaction sequences shown in Figure 1 and 2. Overall radiochemical yields of SL‐573‐4‐ 14 C and SL‐522‐4‐ 14 C were 35% and 17% from carbon dioxide‐ 14 C. and their specific activities were 5.52 mCi/mmole and 3.31 mCi/mmole, respectively.