Premium
The synthesis of N‐nitrosohexamethyleneimine labeled with 14 C in the 2‐position
Author(s) -
Granjean C. J.,
Nagel D. L.,
Wallcave L.,
Phelps K.,
Charnock G.
Publication year - 1973
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590090305
Subject(s) - cycloheptane , yield (engineering) , chemistry , cyclohexanone , ring (chemistry) , nitrosation , product (mathematics) , reduction (mathematics) , radiochemistry , organic chemistry , mathematics , materials science , metallurgy , catalysis , geometry
A synthetic procedure for 2‐ 14 C‐N‐nitrosohexamethyl‐eneimine 1‐aza‐l‐nitroso‐(2‐ 14 C)‐cycloheptane is presented. The starting material was 1‐ 14 C‐cyclohexanone which underwent ring expansion, reduction, and finally nitrosation. The synthesis resulted in a product in good yield (68% overall), which is chemically and radiochemically pure.