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Synthesis of methyl trans ‐(10‐ 14 C)‐retinoate and trans ‐(10‐ 14 C)‐retinol
Author(s) -
Bu'Lock J. D.,
Quarrie S. A.,
Taylor D. A.
Publication year - 1973
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590090214
Subject(s) - yield (engineering) , chemistry , sequence (biology) , stereochemistry , radiochemistry , physics , biochemistry , thermodynamics
The preparation of the title compunds, using β‐ionone, is accomplished in fair overall radiochemical yield from (2‐ 14 C) bromacetic acid, in 7 and 8 steps respectively. The sequence utilises ylid reactions of the phosphonoacetate derived from bromacetic ester, and is also capable of the introduction of label at C‐14.