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The synthesis and purification of 2, 6‐di‐ tert ‐buytl‐ p ‐cresol‐ −14 C 6
Author(s) -
Shipp B. D.,
Data J. B.,
Christian J. E.
Publication year - 1973
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590090115
Subject(s) - cresol , p cresol , chemistry , isobutylene , catalysis , thin layer chromatography , nuclear chemistry , chromatography , organic chemistry , medicinal chemistry , phenol , copolymer , polymer
2, 6‐Di‐ tert ‐butyl‐p‐cresol‐ 14 C 6 was synthesised by reacoting p ‐cresol‐ 14 C 6 with isobutylene using concetentrated sulfurica acid as catalyst. Purification of the Labelled butylated p ‐cresol involved very careful recrystalliation of this product from absolute alcohol. Proof of radiochemical purity was determined using thin layer chromatography and autoradiography. Internal liquid acintillation counting techniques were used to determine the apeacific activity of the compound.