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Synthesis of 1, 3‐dihydro‐1‐methyl‐7‐nitro‐5‐phenyl‐2H‐1, 4‐benzodiazepin‐2‐one‐5‐ 14 c (nimetazepam‐5‐ 14 C)
Author(s) -
Yoshitake A.,
Makari Y.,
Endo M.
Publication year - 1972
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590080410
Subject(s) - yield (engineering) , nitro , chemistry , sequence (biology) , medicinal chemistry , carbon dioxide , stereochemistry , physics , organic chemistry , biochemistry , alkyl , thermodynamics
The synthesis from carbon‐ 14 C dioxide of 1, 3‐dihydro‐1‐methyl‐7‐nitro‐5‐phenyl‐2H‐1, 4‐benzodiazepin‐2‐one‐5‐ 14 C (I) for use in metabolic studies has been described. The synthesis was achieved by the sequence shown in figure 1. The overall yield of labelled nimetazepam (I) was nearly 36%.