Premium
Synthesis of picolinic‐(carboxyl‐ 14 C) acid and 2‐{(methylsulfinyl) acetyl ‐ (carbonyl ‐ 14 C)} pyridine
Author(s) -
Merril E. J.,
Vernice G. G.
Publication year - 1972
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590080406
Subject(s) - picolinic acid , chemistry , pyridine , sodium hydride , lithium (medication) , dimethyl sulfoxide , carbonation , medicinal chemistry , sulfoxide , derivative (finance) , sodium , hydride , organic chemistry , medicine , endocrinology , hydrogen , financial economics , economics
Abstract Picolinic‐ (carboxyl‐ 14 C) acid was prepared by carbonation of the lithio derivative obtatined from n‐butyl lithium and 2‐bromopyridine. This was esterified and allowed to react with the anion generated from dimethyl sulfoxide by sodium hydride to give 2‐[(methylsulfinyl)acetyl‐(carbonyl‐ 14 C)] pyridine.