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Radiation ‐ induced decomposition of radioiodine ‐ labelled 3 ‐ iodo ‐ L ‐ tyrosine
Author(s) -
Appleby A.,
Umfrid R. P.
Publication year - 1972
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590080307
Subject(s) - decomposition , radiolysis , chemistry , ethanol , hydrogen , radiation dose , tyrosine , substrate (aquarium) , radiochemistry , oxygen , organic chemistry , biochemistry , biology , radical , nuclear medicine , medicine , ecology
In investigating the radiolytic decomposition of 3‐iodo‐L‐tyrosine we find : 1 that, by studying the effects of dissolved argon, nitrous oxide and hydrogen, e − aq is the reactive intermediate of greatest interest in choosing a protector of the labelled compound. This technique should have general application. 2 that O 2 / ethanol and N 2 O/ ethanol are both good combinations for the purpose of protecting the substrate. 3 that in dilute solutions of MIT, with adequate protector present, high specific activity compound should be no more prone to radiation‐induced self‐decomposition than is compound labelled at a lower specific activity.Items (2) and (3) should be noted particularly, in view of the widespread belief that high specific activity and the presence of oxygen are always deleterious to the stability of labelled compounde.