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Synthese du methyl‐2 p‐chlorophenyl‐4 pentane diol‐2,4(fenpentadiol) marque AU 14 C
Author(s) -
Noël J. P.,
Benakis A.,
Valette R.,
Herbert M.,
Pichat L.
Publication year - 1972
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590080202
Subject(s) - chemistry , pentane , diazomethane , magnesium , medicinal chemistry , diol , betaine , ethyl bromoacetate , yield (engineering) , nuclear chemistry , organic chemistry , materials science , metallurgy
Methyl‐2 p‐chlorophenyl‐4 pentane diol 2,4 14 C‐4 (Rd 292‐Fenpentadiol), a psychotropic drug, was prepared by means of the action of methyl magnesium iodure on p‐chlorophenyl‐3 hydroxy‐3 ethyl butyrate 14 C‐3. The latter was obtained by means of the Reformatzri reaction between ethyl bromoacetate and p‐chloroacetophenon 14 CO, which was obtained by the action of iodhydric acid on p‐chlorophenyl diazoacetophenon 14 CO, resulting from the action of diazomethane on p‐chlorobenzoyl 14 C chlorure. The necessary p‐chlorobenzoic carboxyl 14 C acid was obtained through carbonatation of p‐chlorphenyl magnesium bromure, free from any isomere a or m. The total yield compared to 14 CO 3 Ba was 31% Specific activity : 25, 3 mCi/mM.