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Preparation of tritium‐labelled phenethanolamines by catalytic reduction
Author(s) -
Comer W. T.,
Roth H. R.
Publication year - 1971
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590070413
Subject(s) - tritium , phenethylamine , hydrochloride , chemistry , catalysis , catalytic hydrogenation , selective catalytic reduction , organic chemistry , radiochemistry , stereochemistry , physics , nuclear physics
Tritium‐labelled plenethanolamines have been readily prepared by catalytic reduction of corresponding α‐aminophenones. Erythro phenethanolamine racemates are exclusively formed by Pd‐catalyzed reduction of α‐alkyl‐α‐aminophenones. In one case, an α‐aminophenone was further reduced by tritium to the phenethylamine, which has never been observed with catalytic hydrogenation under similar conditions. In this manner, three adrenergic agents have been labelled for metabolism and tissue distribution studies: sotalol‐7− 3 H hydrochloride, soterenol‐7− 3 H hydrochloride, and mesuprine‐7− 3 H hydrochloride.