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Radiochemical preparation of 3, 4, 3′, 4,‐tetrachloroazobenzene− 14 C
Author(s) -
Tanaka F. S.,
Wien R. G.
Publication year - 1971
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590070411
Subject(s) - aniline , yield (engineering) , chemistry , azobenzene , ring (chemistry) , radiochemistry , nuclear chemistry , organic chemistry , materials science , molecule , metallurgy
Interest for the preparation of 14 C‐labeled 3,4,3′,4′‐tetrachloroazobenzene for metabolism studies was developed after recent reports indicated that soil micro‐organisms could transform some chlorinated aniline based herbicides into azobenzene compounds. The preparation of tetrachloroazobenzene was carried out in a three‐step synthesis starting with ring− 14 C‐3‐(3,4‐dichlorophenyl)‐1,1‐dimethylurea (Diuron) which was previously prepared in the laboratory. The overall product yield for the synthesis was estimated to be 33.6%, and the specific activity of the labeled material was 252 μCi/mM.