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Preparation of tritium‐labelled D,L‐2,6‐diaminopimelic acid
Author(s) -
Hanuš J.,
Vereš K.
Publication year - 1971
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590070406
Subject(s) - diaminopimelic acid , chemistry , tritium , dehydrohalogenation , ammonia , catalysis , hydroxylamine , nuclear chemistry , radiochemistry , organic chemistry , enzyme , physics , nuclear physics , peptidoglycan
Abstract On hydrogenation of the 2,6‐bis(phenylhydrazone) of 2,6‐diketopimelic acid with carrier‐free tritium a very low specific activity was achieved, due to the labile C‐T‐bonds in the α‐positions. 2,6‐Diaminopimelic‐4− 3 H acid of spec. activity 790 mCi/mmole was obtained by catalytic dehydrohalogenation of 4‐chloro‐2,6‐diaminopimelic acid in 1N ammonia. A new, simple apparatus for catalytic tritiation is also described.