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14 C‐synthesen biologisch interessanter p‐substituierter aryläthan‐körper
Author(s) -
Schiefer S.,
Kindl H.
Publication year - 1971
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590070314
Subject(s) - oxime , chemistry , nitromethane , carbon atom , tyrosol , lithium aluminium hydride , medicinal chemistry , aryl , condensation , aluminum hydride , organic chemistry , lithium (medication) , catalysis , ring (chemistry) , phenols , methoxide , medicine , alkyl , physics , thermodynamics , endocrinology
Abstract p‐Methoxyphenylacetaldehyde oxime‐1− 14 C and p‐hydroxyphenylacetaldehyde oxime‐1− 14 C were synthesized from the corresponding arylnitroethenes. The radioactive carbon atom was introduced by the condensation of p‐substituted benzaldehydes with nitromethane− 14 C. Using preparative thin layer chromatography a convenient procedure is described leading to products with high specific activity. Under certain conditions the reduction of arylnitroethenes yielded predominantly the saturated nitrocompounds. Labelled tyrosol and its derivatives were obtained from the corresponding acids by reduction with lithium aluminium hydride.