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Small‐scale degradation of carbon‐14 labelled carboxylic acids. I. Modification of the hunsdiecker reaction
Author(s) -
Susan A. B.,
Nystrom R. F.
Publication year - 1971
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590070311
Subject(s) - chemistry , acetic acid , bromine , bromide , carbon fibers , degradation (telecommunications) , butyric acid , salt (chemistry) , barium hydroxide , nuclear chemistry , carboxylic acid , carbon 14 , organic chemistry , telecommunications , materials science , physics , quantum mechanics , composite number , computer science , composite material
A modified Hunsdiecker reaction is described for the degradation of the silver salts of acetic acid‐1− 14 C, acetic acid‐2− 14 C, propionic acid‐1− 14 C, propionic acid‐3− 14 C, n‐butyric acid‐1− 14 C and n‐butyric acid‐2− 14 C to carbon dioxide, silver bromide and an organic bromide containing one less carbon atom than the acid, on a 0.5 to 10 millimole scale. This reaction is performed by allowing the silver salt of a carbon‐14 labelled acid to react with bromine vapor in a sealed tube. Then the separation, purification and determination of the amount of each degradation product is accomplished by use of high vacuum techniques. Finally, the products which are obtained in a radiochemically pure form are analyzed for radioactivity by liquid scintillation counting.