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The synthesis and purification of pentachloro‐phenol− 14 C 6
Author(s) -
Rogers R. R.,
Christia J. E.,
Etzel J. E.,
Born G. S.
Publication year - 1971
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590070208
Subject(s) - pentachlorophenol , phenol , chemistry , liquid scintillation counting , aqueous solution , hydrochloric acid , precipitation , chloride , alkali metal , chromatography , nuclear chemistry , phenols , inorganic chemistry , organic chemistry , physics , meteorology
Pentachlorophenol− 14 C 6 was synthesized by chlorinating phenol− 14 C 6 using aluminum chloride as a catalyst. Purification of the labeled pentachlorophenol involved the precipitation of the labeled product from an aqueous alkali solution with hydrochloric acid and two sublimations. Proof of radiochemical purity was determined using thick layer chromatography and autoradiography. Internal liquid scintillation counting techniques were used to determine the specific activity of the compound.